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pentobarbital decreases amounts of toremifene by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check. CYP3A4 inducers raise charge of toremifene metabolism, reducing the continuous-point out concentration in serum.pentobarbital will reduce the extent or result of disopyramide by affecting hepatic/intestinal enzyme CYP3A4 metabo